Description

Position Overview

The Holmstrom Lab at the University of Kansas invites qualified candidates to submit applications for the position of Single-Molecule Biophysics Postdoctoral Research Assistant. The selected applicant will work in the laboratory of Prof. Holmstrom, where state-of-the-art single-molecule fluorescence techniques are employed to study the molecular mechanisms of functional nucleic acids and the various proteins that interact with them. This multidisciplinary research environment integrates concepts from biology, chemistry, physics, computer science, and engineering to measure the structural and dynamic properties of individual biomolecules using spectroscopic techniques such as single-molecule Forster Resonance Energy Transfer (FRET) and cryogenic electron microscopy (cryoEM) single-particle reconstruction.

The Holmstrom lab seeks highly motivated individuals who possess strong interpersonal skills and a passion for scientific research. The ideal candidate holds a PhD in biochemistry, molecular biology, chemistry, physics, engineering, or a closely related field in single-molecule biophysics. Candidates should also have extensive research experience in fluorescence spectroscopy/microscopy and protein/nucleic acid purification. A strong record of scientific achievements, including peer-reviewed publications and scientific presentations, is required. Proficiency in both oral and written English is essential. Research experience with single-molecule methods, FRET, cryoEM, microfabrication, and/or data analytics is strongly preferred but not mandatory.

Job Description

50% Laboratory work: Prepare buffers/samples; develop experimental techniques; design and conduct experiments; analyze data; keep detailed notes and records pertaining to this laboratory work.

30% Dissemination: Read scientific literature related to all aspects of the research project; generate posters and digital presentations; assist in the preparation and submission of all manuscripts and publications related to the research project.

10% Laboratory Maintenance: Help clean, organize, and maintain a safe laboratory environment; know up-to-date laboratory safety protocols and employ them in the laboratory.

10% Other duties: Attend and participate in scientific group meetings and departmental seminars; assist in the mentorship and training of students at both the graduate and undergraduate levels.

Position Requirements

Work location: Onsite

Required Qualifications

1. PhD in biochemistry, molecular biology, chemistry, physics, engineering, or another field closely related to single-molecule biophysics.
2. A strong record of scientific accomplishments, including peer-reviewed publications and scientific presentations, as demonstrated in application materials.

NOTE: To be appointed at the Postdoctoral Researcher title, it is necessary to have the PhD in hand. Appointments made without a diploma or certified transcript indicating an earned doctorate are conditional hires and are appointed on an acting basis not to exceed 6-months.

Additional Candidate Instruction

Interested candidates should submit an online application that contains of the following items:

1. Cover letter detailing scientific interests and prior research experience as well as career goals
2. Detailed CV with publication record and contact information for a potential interview
3. Contact information for three professional references

Application review begins Friday, January 2nd, 2026 and will continue until a qualified pool of applicants are identified.

Disclaimer

The University of Kansas prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression, and genetic information in the university's programs and activities. Retaliation is also prohibited by university policy. The following person has been designated to handle inquiries regarding the nondiscrimination policies and procedures and is the Title IX Coordinator for all KU and KUMC campuses: Associate Vice Chancellor for the Office of Civil Rights and Title IX, civilrights@ku.edu, Room 1082, Dole Human Development Center, 1000 Sunnyside Avenue, Lawrence, KS 66045, 785-864-6414, 711 TTY. Reports can be submitted by contacting the Title IX Coordinator as provided herein or using the Title IX online report form and complaints can be submitted with the Title IX Coordinator or using the Title IX online complaint form.