Description
The Italiano Laboratory at Boston Children’s Hospital and Harvard Medical School is seeking a highly motivated Postdoctoral Scholar to investigate the biology of megakaryocytes, with emphasis on understanding the role of the cytoskeleton in platelet production as well as newly described functions of megakaryocytes in disease.
Our laboratory is recognized for foundational discoveries defining the cell biological mechanisms that regulate platelet generation, and we are now uncovering new functions for megakaryocytes beyond platelet biogenesis. These studies open a new chapter in megakaryocyte biology. For example, we are investigating how cytokine secretion from megakaryocytes contributes to myelofibrosis.
The laboratory is in the Vascular Biology Program in the Longwood Medical Area adjacent to Harvard Medical School. This position is ideal for early-career scientists eager to develop a strong publication record and lead mechanistic and translational NIH -funded projects.
Research Areas:
Cytoskeletal and cell cycle regulation of proplatelet generation in megakaryocytes
Examining how megakaryocytes contribute to myelofibrosis
The science behind megakaryocyte heterogeneity
Using bioengineering to understand how megakaryocytes breach the endothelium to deposit platelets in the blood
Drug-induced thrombocytopenia
Key Responsibilities:
Design and perform hematological and cellular experiments
Cutting-edge Microscopy
Flow cytometry analysis and sorting
Gene perturbation (transfection, knockdown/knockout)
Data analysis, presentation, manuscripts, and conference abstracts
Collaboration and mentoring of students
Why Boston Children’s Hospital / Harvard Medical School?
State-of-the-art imaging and flow cores
Strong hematology and platelet community
Unlimited resources and collaborations
High-level mentorship with emphasis on career development
Application
Send a CV, cover letter, and contact information for 3 references to: Dr. Joseph Italiano
Email: joseph.italiano@childrens.harvard.edu
Requirements
PhD in cell biology, hematology or closely related field
Strong background in the cytoskeleton, megakaryocytes, or platelets
Experience with microscopy, flow cytometry, megakaryocytes, or mouse models
Excellent communication skills and scientific rigor