Description

At Insmed, every moment and every patient counts - and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's contributions to meaningful progress. That commitment has earned us recognition as Science magazine's No. 1 Top Employer for four consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we're in. Are you?

About the Role:
We're seeking a highly motivated, creative, and passionate Senior Scientist to join our multidisciplinary team advancing therapeutics for inflammatory and autoimmune diseases. In this role, you will lead the development, optimization, and validation of in vitro functional and translational assays, drive microscopy experiments from execution through interpretation, and collaborate across functions to support downstream analyses from in vivo studies.

What You'll Do:

• Lead cell-based assay development, perform efficacy assessment across primary and follow-up compound screens, and support data-driven decisions for Insmed projects.
• Isolate and culture primary immune cells (neutrophils, hematopoietic stem/progenitor cells, mouse bone-marrow progenitors) and maintain common lines (e.g., Jurkat, THP-1, HL-60, RAW264.7) and other relevant cell lines for in vitro/ex vivo assays.
• Plan and execute experiments using molecular biology techniques, including Western blot, ELISA, Luminex multiplex immunoassays, PCR, and qPCR.
• Perform antibody-based immunostaining, including immunohistochemistry and immunofluorescence, to detect and localize protein targets in tissue sections and cultured cells.
• Conduct microscopy and analysis in partnership with computational scientists, help transition to a high-throughput, AI-driven workflow.
• Execute multicolor flow cytometry across immune and non-immune cell types, and perform high-purity FACS sorting of rare populations.
• Support downstream analyses from in vivo studies, including sample collection, processing, and ex vivo measurements.
• Maintain accurate, detailed, and timely electronic records of method development, experimental data, analyses, and summaries, and generate internal technical reports as needed.
• Perform data QC and statistical analyses to ensure accuracy, completeness, and validity, using Excel, XLfit, GraphPad Prism, and FlowJo.
• Conduct literature reviews to inform study design and program strategy.
• Ensure proper maintenance of laboratory equipment.
• Present scientific results at internal and external meetings as needed.

Who You Are:

• PhD and 5+ years of experience in molecular and cellular biology, bioengineering, biochemistry, immunology, microbiology, or related field.
• Must have hands-on experience with cell culture, in vitro assays, and developing/optimizing standard molecular biology assays.
• Must have deep expertise in imaging related techniques such as fluorescent microscopy, confocal microscopy, and high-content imaging system.
• Must have strong expertise in immunohistochemistry and immunofluorescence staining.
• Experience working with downstream sample processing from preclinical animal models is a strong plus.
• Experience handling animals such as dosing, in-life behavior assessment, and lung function measurements is a strong plus.
• Deep knowledge of cell biology, immunology, immune-oncology, or neuroscience/neuronal cell biology is a strong plus.
• Familiarity with microglia/astrocyte co-cultures, neuroinflammation assays, and BBB models is a plus.
• Clear, effective written and verbal communication and strong problem-solving skills are required.
• A high degree of organization and time-management skills, with meticulous attention to detail to ensure clarity, accuracy, and concision, are required.
• A strong sense of enthusiasm and self-motivation is required.
• Ability to work collaboratively and efficiently in a team environment is essential.
• Must successfully exhibit Insmed's five (5) core corporate values: Passion, Accountability, Collaboration, Integrity and Respect.

Pay Range:
$104,000.00-137,800.00 Annual

Life at Insmed

At Insmed, you'll find a culture as human as our mission-intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Highlights of our U.S. offerings include:

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

Insmed Incorporated is an Equal Opportunity employer. We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at TotalRewards@insmed.com and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.